Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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1. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity associated with bortezomib, a proteasome inhibitor Utilized in the cure of many myeloma. Its synthesis or review is critical for making certain the purity and protection with the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor within the synthesis of abiraterone acetate, a drug Employed in the remedy of prostate cancer by inhibiting androgen generation.
Imatinib Intermediate (CAS NO. 152460-10-one): A essential compound within the synthesis of imatinib, a drug that targets precise sorts of cancer, which include Continual myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats various cancers for instance breast, lung, and prostate cancer.
2. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): These are generally intermediates in the synthesis of gemcitabine, an anti-most cancers drug. Their study is crucial for optimizing the creation process and ensuring superior purity.
Lapatinib Intermediate (CAS NO. 231278-84-5): Lapatinib is utilised to take care of breast cancer, and these intermediates are involved with its output.
Fulvestrant CAS NO. 136572-09-3 Intermediates: Fulvestrant is surely an estrogen receptor antagonist Utilized in the treatment of breast cancer. Several intermediates assist in the synthesis of the drug.
Paclitaxel Aspect Chain Acid (CAS NO. 949023-sixteen-nine): This intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug effective in treating cancers including ovarian, breast, and lung cancer.
three. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Employed in the treatment of colorectal cancer and tiny cell lung cancer.
3-Amino-1-hydroxyadamantane (CAS 702-82-9): This compound is involved with the synthesis of adamantane derivatives, which have numerous apps, which include antiviral Attributes.
Vildagliptin Intermediates: Employed in the creation of vildagliptin, an oral drug for style two diabetic issues that inhibits the enzyme DPP-four to manage blood sugar levels.
four. Miscellaneous Compounds
D-Gluconic Imatinib intermediate Acid δ-Lactone (CAS NO. 61259-forty eight-one): This compound is involved with the synthesis of varied gluconic acid derivatives, which might be Utilized in food items, pharmaceutical, and industrial apps.
Canagliflozin Intermediate 2: A precursor inside the synthesis of canagliflozin, a medication utilized to handle kind two diabetic issues by inhibiting sodium-glucose co-transporter 2 (SGLT2).